Obtaining entirely new insights in the mechanisms that underlie autoimmune diseases, leukemia, and carcinomas.
Core business
The Roose Lab is founded by Dr Jeroen Roose, alumnus of Utrecht University. Dr Roose is a tenured Principal Investigator and Vice Chair of Anatomy at the University of California, San Francisco (UCSF). The Roose lab studies the impact Ras-kinase signals have on cell fate decisions in health and disease. The Roose lab team explores three cell fates and disease types: T-cells causing autoimmunity, bone marrow progenitors in leukemias, and epithelial stem and progenitor cells in carcinomas. By taking a collaborative approach and working with biophysicists, computational engineers, geneticists, and many clinicians, the Roose research team spans the gamut from fundamental science to pre-clinical trials.
Roose Lab and UCSF scientists have designed a large-scale screening that efficiently identifies drugs that are potent cancer-killers when combined, but only weakly effective when used alone.
Dr Jeroen Roose states that “many cancers either fail to respond to a single targeted therapy or acquire resistance after initially responding. The notion that combining targeted therapies is a far more effective way to treat cancer than a single-drug approach has long existed. We wanted to perform screens with saturating coverage to understand exactly what combinations should be explored.”
Source: cancer.ucsf.edu
About the company
The Roose Lab Our lab is a highly collaborative, diverse, international, and ambitious group of approx 15 staff members, students and postdocs. The group enjoys team-based research that capitalizes on the strength of the individual. The lab is part of UCSF’s Department of Anatomy, located near Golden Gate Park.
Affiliated Interns
Marcela García Jiménez
Research Scholar
